Breast Cancer awareness starts with prevention.

Breast Cancer awareness starts with prevention.
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For many, this shift quietly affects energy, mood, sleep and overall quality of life. Bioidentical hormone replacement therapy is one approach that prescribers may consider when addressing these changes. BHRT uses hormones that are structurally identical to those the body produces naturally, and a compounding pharmacy can prepare customized formulations in the strength and delivery method a prescriber specifies. Options may include implantable pellets, topical creams and gels, sublingual tablets or injectable testosterone. It is also worth knowing that current research does not support the long-held fears about testosterone therapy and heart disease or prostate cancer risk, both of which have been significantly revised by modern evidence. For those looking to support their wellness now, over-the-counter options such as Pro-Balance DHEA and Pro-Balance Vitamin D3 5,000 IU are available for immediate purchase without a prescription.
I finally feel like I have a team that listens to me and takes the time to explain everything. It is reassuring to know that my provider and pharmacist are working together to support my health.
Costs vary depending on the type of medication, dosage form and frequency of use. Because compounded medications are customized, pricing is determined on a per-prescription basis. Speak with a pharmacist to get a clearer picture of what to expect for your specific prescription.
When prescribed and monitored appropriately, hormone therapy may support improvements in energy, mood, sleep quality and body composition. Research also suggests that maintaining adequate testosterone levels may be associated with reduced cardiovascular risk markers and, contrary to older assumptions, does not appear to increase prostate cancer risk.[9][13] Many men who pursue informed conversations with their providers about hormone health report feeling more like themselves again. Individual responses vary, and your healthcare provider can help you understand what may be relevant for your situation.
Current evidence does not support this concern. The 2024 Androgen Society position statement, based on the large TRAVERSE trial and a review of 19 meta-analyses, concluded that testosterone therapy is not associated with increased risk of heart attack, stroke or cardiovascular death.[9] In fact, research consistently links low testosterone, not adequate testosterone, with higher rates of coronary artery disease and cardiovascular events in men.[10] Addressing hormone deficiency with your provider may be a meaningful step toward supporting long-term heart health.
Research has significantly changed the understanding of this relationship. The saturation model, developed at Harvard Medical School, demonstrates that normal physiological testosterone levels do not continue to stimulate prostate tissue growth in a linear fashion.[12] A systematic review of 40 prospective studies found no association between testosterone therapy and prostate cancer incidence, and studies have actually found higher rates of prostate cancer in men with the lowest testosterone levels.[13] Your healthcare provider will evaluate your full history and monitor appropriately, which is standard care for all patients on hormone therapy.[7]
They are not the same. Bioidentical testosterone therapy uses hormones that are structurally identical to what the body produces naturally, prescribed at doses calibrated to restore physiologically appropriate levels, and monitored over time by a licensed healthcare provider.[2] Nonmedical anabolic steroid use typically involves synthetic compounds at doses far exceeding normal ranges, without clinical oversight. Medically supervised BHRT is a well-studied, provider-directed approach to restoring hormonal balance.
Not necessarily. The 300 ng/dL threshold was developed from samples of older men and may not reflect what is physiologically normal for a younger individual.[14] Research published in the Journal of Urology found that age-appropriate testosterone ranges for men in their 30s are meaningfully higher, suggesting this cutoff alone can miss deficiency in younger men.[14] Symptoms, quality of life and overall health context are all important parts of a complete evaluation alongside laboratory values.[2] If you are experiencing changes in energy, mood, sleep or physical performance, that conversation with your provider is worth having regardless of a single number.
Decisions about starting, adjusting or discontinuing therapy should be made in consultation with your healthcare provider. Stopping therapy may affect hormone levels and how you feel, so it is important to have an open conversation about your goals and any concerns before making changes.[2]
Compounding pharmacies can prepare testosterone in several forms, including transdermal creams, gels, sublingual tablets, injectable solutions and implantable pellets.[6] The form prescribed depends on your healthcare provider’s assessment of which option offers the most appropriate absorption and tolerability for your individual needs.
If you do not currently have a provider who specializes in hormone health, a compounding pharmacy may be able to help connect you with practitioners in your area who offer this type of care. You can also ask your primary care physician for a referral.
[1] Endocrine Society. Hypogonadism in Men. https://www.endocrine.org/patient-engagement/endocrine-library/hypogonadism
[2] American Urological Association. Testosterone Deficiency Guideline. https://www.auanet.org/guidelines-and-quality/guidelines/testosterone-deficiency-guideline
[3] Cleveland Clinic. Why Are Testosterone Levels Declining? https://health.clevelandclinic.org/declining-testosterone-levels
[4] Mulligan T, Frick MF, Zuraw QC, et al. Prevalence of hypogonadism in males aged at least 45 years: the HIM study. Int J Clin Pract. 2006;60(7):762-769.
[5] Harman SM, Metter EJ, Tobin JD, et al. Longitudinal effects of aging on serum total and free testosterone levels in healthy men. J Clin Endocrinol Metab. 2001;86(2):724-731.
[6] National Academies of Sciences, Engineering, and Medicine. Testosterone and Aging: Clinical Research Directions. Washington, DC: The National Academies Press. https://www.ncbi.nlm.nih.gov/books/NBK216175/
[7] Bhasin S, et al. Testosterone Therapy in Men with Hypogonadism: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2018.
[8] Lokeshwar SD, Patel P, Fantus RJ, et al. Decline in serum testosterone levels among adolescent and young adult men in the USA. Eur Urol Focus. 2021;7(4):886-889. https://pubmed.ncbi.nlm.nih.gov/32081788/
[9] Morgentaler A, et al. Androgen Society Position Paper on Cardiovascular Risk With Testosterone Therapy. Mayo Clin Proc. 2024. https://www.mayoclinicproceedings.org/article/S0025-6196(24)00408-7/fulltext
[10] Sharma R, et al. Testosterone and Cardiovascular Health. Mayo Clin Proc. 2018;93(1):83-100. https://www.mayoclinicproceedings.org/article/S0025-6196(17)30824-8/fulltext
[11] Haddad RM, et al. Adverse cardiovascular events and mortality in men during testosterone treatment: an individual patient and aggregate data meta-analysis. Lancet Healthy Longev. 2022. https://pmc.ncbi.nlm.nih.gov/articles/PMC9184259/
[12] Morgentaler A, Traish AM. Shifting the paradigm of testosterone and prostate cancer: the saturation model and the limits of androgen-dependent growth. Eur Urol. 2009;55(2):310-320. https://pubmed.ncbi.nlm.nih.gov/18838208/
[13] Kaplan AL, et al. Testosterone therapy in men with prostate cancer. Eur Urol. 2016. https://pmc.ncbi.nlm.nih.gov/articles/PMC5000551/
[14] Kelsey TW, et al. What is a normal testosterone level for young men? Rethinking the 300 ng/dL cutoff for testosterone deficiency in men 20-44 years old. J Urol. 2022. https://www.auajournals.org/doi/10.1097/JU.0000000000002928
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